The 20:15 GMT kick-off at St James' Park is fast approaching, but there is still time for you to play the free United Predictions game in our app.
The aim is to score as many points as you can by trying to correctly guess the Reds' starting XI, first scorer and Man of the Match, as well as the final result.
Before we tell you more about the rules and prizes up for grabs, here's a look at the picks of former United defenders Phil Bardsley and Wes Brown...
PHIL BARDSLEY'S PREDICTIONS
Phil thinks Michael Carrick will make just the one change to his XI, predicting Noussair Mazraoui to come in at left-back for Luke Shaw, who the boss hopes will still be able to play a part on Wednesday despite being forced off in the first half of Sunday's win with illness.